Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cysteine | activates | Porphyromonas gingivalis |
Application | Comment | Organism |
---|---|---|
medicine | development of structure-based inhibitors for treatment of periodontal diseases | Porphyromonas gingivalis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Chloromethyl ketones | development of diverse inhibitor derivatives: structure-based design, chemistry, and activity, specificity for the Sn binding pocket of the enzyme, overview | Porphyromonas gingivalis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted | Porphyromonas gingivalis | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Porphyromonas gingivalis | gingipains are essential for bacterial virulence and survival | ? | - |
? | |
additional information | Porphyromonas gingivalis HG66 | gingipains are essential for bacterial virulence and survival | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Porphyromonas gingivalis | - |
- |
- |
Porphyromonas gingivalis HG66 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native extracellular enzyme from culture medium | Porphyromonas gingivalis |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
endopeptidase with strict specificity for lysyl bonds | active site structure, role of the Sn binding pocket, molecular basis for substrate specificity | Porphyromonas gingivalis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | gingipains are essential for bacterial virulence and survival | Porphyromonas gingivalis | ? | - |
? | |
additional information | role of the Sn binding pocket, molecular basis for substrate specificity, overview | Porphyromonas gingivalis | ? | - |
? | |
additional information | gingipains are essential for bacterial virulence and survival | Porphyromonas gingivalis HG66 | ? | - |
? | |
additional information | role of the Sn binding pocket, molecular basis for substrate specificity, overview | Porphyromonas gingivalis HG66 | ? | - |
? | |
N-p-tosyl-Gly-Pro-Lys-4-nitroanilide + H2O | - |
Porphyromonas gingivalis | N-p-tosyl-Gly-Pro-Lys + 4-nitroaniline | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | structure homology modeling | Porphyromonas gingivalis |
Synonyms | Comment | Organism |
---|---|---|
KGP | - |
Porphyromonas gingivalis |
Lys-gingipain | - |
Porphyromonas gingivalis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Porphyromonas gingivalis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Porphyromonas gingivalis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics, overview | Porphyromonas gingivalis |